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New trial targets high blood pressure

At St Bartholomew's Hospital we're trialling a new device that reshapes the carotid sinus to reduce blood pressure while maintaining normal blood flow.

A new clinical trial, called CALM-2 (Controlling And Lowering blood pressure with MobiusHDÒ), sponsored by California-based Vascular Dynamics, Inc. (VDI), is a novel endovascular approach to treat patients with drug-resistant high blood pressure.

High blood pressure, or hypertension, is recognized as the most important single risk factor for cardiovascular morbidity and death. Despite advances in the effectiveness of medications, many people struggle to control their blood pressure to targeted levels, despite antihypertensive medications. For these people and their loved ones, the need for a non-pharmaceutical treatment has become of critical importance. 

Specialized stretch-sensitive nerves, called baroreceptors, are located in the walls of the carotid arteries and play an essential role in the body’s natural blood pressure regulation. Vascular Dynamics has developed the first catheter-based, non-surgical approach that utilizes the baroreceptor mechanism to address uncontrolled hypertension. This approach includes placement of the MobiusHD implant, a thin rectangular-shaped device designed to reshape the carotid sinus to increase baroreceptor stretch and amplify nerve signaling to the brain. This serves to reduce blood pressure while maintaining normal blood flow and beat-to-beat fluctuations.

“The consequences of high blood pressure represent a tremendous unmet clinical need, and a non-pharmaceutical solution is needed,” said Principal Investigator Professor Melvin Lobo from Queen Mary University of London and Barts Health NHS Trust.

“The initial results using the MobiusHD implant to reshape the carotid sinus and stretch baroreceptors to trigger the body’s natural blood pressure regulation is impressive and of great interest to us. The safety and efficacy for this approach must be confirmed in a larger clinical trial, and we look forward to being an integral part of this important study.”

Enrollment for the CALM-2 study has begun at select medical centers around the UK, Europe and the U.S. with Professor Lobo leading these efforts at St Bartholomew’s Hospital.

The MobiusHD device was studied in an earlier proof-of-concept study, and results were published in 2017, showing significant reductions in blood pressure through six months after implantation.  These encouraging results led to the design of the larger multi-center clinical trial, CALM-2, intended to generate definitive evidence of safety and effectiveness of this approach.

Visit to learn more about the study.

Further background on the MobiusHD device is available at:


Add a response »
  1. alberto crisci Wednesday, 20 February 2019 at 12:03 PM

    Hew do I apply to take part in the trial, i am on 3 types of medication for hypertension and my blood pressure is still high.

  2. James Kearney Wednesday, 5 June 2019 at 12:38 PM

    how do I apply to become part of the trial, I am on more than three types of medication and my blood pressure remains high. I would welcome an alternative way of controlling my blood pressure.
    regards James Kearney 07768503962

  3. William Friday, 7 June 2019 at 09:03 AM

    I heard about this yesterday on LBC Radio and would be interested to learn more and to even become involved.
    Kindest regards
    William (McEwen)

  4. Fred Allen Wednesday, 3 July 2019 at 09:55 AM

    Fred am interested in this please email me back thanks Fred Allen

  5. Simon Onyutha Wednesday, 10 July 2019 at 09:57 AM

    I have just heard about this trial.Could you please enroll me
    in it as well ?

  6. Linda Marks Wednesday, 10 July 2019 at 10:34 AM

    How do I apply to take part in the trial? I am on two types of blood pressure medication.
    Many thanks

  7. williams Mayer Wednesday, 13 November 2019 at 10:02 PM

    Hello! I am a 54 year old man weigh around 243 pounds having high blood pressure problem from last 9 to 12 months just recently started taking medication as advised I don’t smoke neither drink but I am not getting the cure as this problem is effecting my daily life and overall health on a daily basis once my highest ever HBP reading was 180/100 that time I was completely shocked second time 4 days later it came 170/100 means this thing is not in a mood to leave me I was completely scared about my life and want a permanent cure to get rid of this problem permanently, But it seems not to find any kind of help as I’m too worried for such problem just wanting a permanent cure, So it may never ever effect me in future if possible...Couple of few weeks later a friend of mine suggested i tried a herbal doctor called Dr. Aloma who uses herbal medication to cure related diseases like (HSV 1/2 (HEP B/C (CANCER (HPB (HIV (BAD BREATH) I contacted him and explained my health situation to him few days later the medication was delivered to me here in UK, After sticking to him as instructed i was totally cured from HBP, Contact him today if you suffering from such diseases via (

  8. Terence Harold Parkinson Friday, 17 January 2020 at 01:50 PM

    I take 2 tablets a a day,im a bricklayer have a very active job, i feel fine, but i no it's the silent killer.
    My birthday 13/07/1966

  9. Kathleen brundish Tuesday, 21 January 2020 at 09:01 AM

    I am a 69yo female, I have had high blood pressure for a number of years,about 16years ago I had a heart attack at the time I had insurmountable stress that contributed to my heart attack test proved I had no blockages so was put on medication to reduce my blood pressure. My blood pressure has never been controlled.i am about to add a third drug for high blood pressure that I am reluctant to do. I have family history of high blood pressure, with deverstating consequences. Would like to find an alternative to drugs hence why I am in touch.

  10. Jason sene Tuesday, 21 January 2020 at 12:36 PM

    I to heard about this on LBC radio and would like to be considered for trials

  11. Sheree Wallace Tuesday, 21 January 2020 at 04:14 PM

    I am a 63 year old woman who suffers from hypertension, hypothyroidism, duplex kidneys etc and I'm on 3 different medications for the high blood pressure. Please email me details of the current device-led trial so I can decide whether to take part. Many thanks.

  12. Remo Terroni Tuesday, 21 January 2020 at 05:31 PM

    I am 76 and have high blood pressure for the last 30+years avg 180/76 and I am on 9 tablets a day. I am interested in joining the clinical trial.
    Please let me know how to join.

  13. Mr Justyn Fry Wednesday, 22 January 2020 at 10:23 AM

    I would be really interested to learn more and possibly get involved

  14. Paul Rowley Tuesday, 10 March 2020 at 10:41 AM

    I have been on hypertension medication for many years and am interested in taking part in the trial.

  15. Sarita Gulati Tuesday, 10 March 2020 at 11:21 AM

    I just heard this on LBC. I suffer from high blood pressure and am on two tablets. Would love to take part if I can.

  16. Charnjit Kaur Tuesday, 10 March 2020 at 11:51 AM

    How do I apply to register for the study? As my GP is struggling to control my BP. Thanks

  17. Michael Theaker Tuesday, 10 March 2020 at 08:23 PM

    I was selected to be put forward for the trial in December 2019 and my details were sent to your Manchester Team.
    However I have not heard anything from them. Could you please investigate for me
    Kind Regards
    Michael Theaker

  18. Emmanuel Osehi Tuesday, 10 March 2020 at 09:18 PM

    I will like to take part in the study.

  19. Debbie Baker Tuesday, 10 March 2020 at 10:19 PM

    I am a 59 year old female I am on fuor different medications to control my BP - I am interested in your trial.

  20. Mark Douglas Wednesday, 11 March 2020 at 09:56 AM

    I heard about this yesterday on LBC Radio and would be interested to learn more and to even become involved the trials.
    Kindest regards
    Mark Douglas

  21. philip chambers Wednesday, 11 March 2020 at 10:05 AM

    Hi my name is philip chambers, I'm interested in your trial blood pressure you are raniing , that I heard on LBC radio; would love to have more information please.

  22. Michael Dempsey Wednesday, 11 March 2020 at 10:21 AM

    I would be interested I at present take 6 pills a day

  23. Barry Taylor Wednesday, 11 March 2020 at 10:32 AM

    I’m 66years old and am now on 4 medications for hypertension control. I would very much be interested in controlling this.

  24. Veronica Wednesday, 11 March 2020 at 10:54 AM

    I. As m several years on meds am 63 this year . Have been hospitalised after both went off the scale .it still is unstable

  25. Kabu Charway Wednesday, 11 March 2020 at 10:56 AM

    Any real advancement in medicine and medical technology for the purpose of treatment and improving quality of health/life is a good news

  26. Steve Rolfe Wednesday, 11 March 2020 at 10:56 AM

    Hi I am 66 year old male and take 7 tablets a day and would be interested in taking part in your study.

  27. Randhir Nahar Wednesday, 11 March 2020 at 11:45 AM

    Dear Sir / Madam,
    Please may I be considered to partake in the
    ongoing clinical trials. Best wishes, Rands.

  28. Andy Pearce Wednesday, 11 March 2020 at 11:50 AM

    Like many of the other posts, I heard your advert on LBC yesterday and would be interested in getting involved in the trial. I am 68 years old, cycle about 120 miles a week, and have had high blood pressure since 1996 at least. It's on the borders of being controlled at around 140/80, but I've tried many combinations of drugs - most of which have had unacceptable side effects.

  29. Maggi Merritt Wednesday, 11 March 2020 at 06:32 PM

    I am very interested in taking part in the BP study.
    How do I apply

  30. Maurice Chernick Thursday, 12 March 2020 at 01:00 AM

    Hi. I’d like to apply to participate in the trial. I’m on Perindopril and Amlodopine. Blood pressure still high.

  31. Saila Anandan Thursday, 12 March 2020 at 04:37 AM

    Would like to become a patient to trial, please let me know what is needed of me, thank you

  32. Fred Rivett Thursday, 12 March 2020 at 05:27 AM

    I have suffered with high blood pressure for many years.
    Is it possible to join the study?

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  34. MR K J BROWN Wednesday, 8 July 2020 at 03:53 PM

    Enquiries for any trials please ( especially high blood pressure )
    Many thanks Karl Brown

  35. Anthony Knight Thursday, 17 September 2020 at 08:03 AM

    I am on several blood pressure meds but still with high pressure. I live in London how can I be assessed for the trail?
    Tony Knight
    07949 058929

  36. Felix Cudjoe Thursday, 17 September 2020 at 09:30 AM

    I'm interested in your new trial targeting high blood pressure.

  37. Kim Menen Thursday, 17 September 2020 at 04:38 PM

    please enroll me. I am on several HBP medications and my Father died of a stroke and had HBP all his life.
    I have heard about a connection between Kidneys an HBP many years ago so this is a fantastic step forward.
    Please enroll me
    Kim from Primrose Hill North West London

  38. David Haines Thursday, 17 September 2020 at 07:38 PM

    I am 67 year old Male. I have been on 20mg Lecandipine for 2 years after a sudden spike in BP which lasted one day. Atrial Flutter occurred three months later. I have a slow pulse rate so a pacemaker was fitted a year ago to act as a barrier should I need a beta blocker. Flutter is very infrequent. Recently for some reason I had another spike in BP. This has resulted in 2.5 mg of Ramipril added to the “mix”
    I would be very pleased to be part of this trial. I live in South Wales and will cooperate fully.
    I believe my enthusiasm and willingness would be an asset.

  39. Sampson kota Friday, 18 September 2020 at 12:52 AM

    Hi can l take part in the trial
    I have a very high blood pressure and l have solitary kidney and on eight blood pressure control tablets

  40. Emma Scott Friday, 18 September 2020 at 06:13 PM

    I would be interested and would like to participate in this new trial please.
    Many thanks.

  41. Jacqueline lees Monday, 21 September 2020 at 01:53 AM

    I’m very interested clinical trial .I have hypertension for many years

  42. Colin Bowman Monday, 21 September 2020 at 04:32 PM

    Are you still looking for volunteers with hypertension to join your trial?

  43. Candy Tuesday, 22 September 2020 at 06:32 PM

    I would very much like to be part of your programme. As I have suffered immense. Trying all ways to reduce or rid of BP.
    Heard your advert on LBC. SEPT.2020.

  44. Ingrid Majd Wednesday, 23 September 2020 at 10:34 AM

    I would like to take part in your study, I am a 70 year old female, I have been taking two medications for my hypertension for a number of years now, my blood pressure is stable but still on the higher side. I heard about your study whilst listening to LBC radio.
    Thank you

  45. Andrew wilcox Wednesday, 23 September 2020 at 01:35 PM

    I would like to participate in the trial.

  46. Tracey Brench Monday, 8 March 2021 at 02:51 PM

    On o good day my BP is130, on a bad day 170.

  47. Mike Davies Saturday, 13 March 2021 at 12:01 PM

    Heard your promo on LBC and would like to enrol in the BP study. I take two medies for BP following bypass surgery in USA a few years back. Please contact me with further instructions. Mike Davies. Tks.

  48. B Pakoue Friday, 26 March 2021 at 10:59 PM

    I am a 44 year old female who has been suffering with hypertension since the age of 19. I am a survivor of a stroke and despite having been a lover of all things healthy, being a fitness fanatic and being on medication, my blood pressure is still not undercontrol.

  49. Peter Mills Saturday, 27 March 2021 at 11:46 AM

    I take 2 types of medication for hypertension and would be interested in participating in your study. I am 55.

  50. Ken Bell Friday, 30 April 2021 at 06:42 PM

    I’m very interested your clinical trial. I have had hypertension for many years.
    Best Wishes
    Ken Bell

  51. Claire McMullan Sunday, 6 June 2021 at 12:48 PM

    I’m interested in taking part in this study. Please can you send me more info?
    Many Thanks

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  53. Stephen Renny Sunday, 10 April 2022 at 11:53 PM

    I’m on 3 medications for high blood pressure and I’m 55 years old and not diabetic

  54. Amar Saggar Monday, 17 October 2022 at 12:05 PM

    I heard about this today on LBC Radio and would be interested to learn more and to even become involved.
    Please advise next steps.

  55. David Stapley Sunday, 23 October 2022 at 03:04 PM

    Hi, I am 66 years old. I was diagnosed with hypertension 17 years ago. I am on 10mg. Amlodipine daily. Which appears to control my blood pressure. Should I be interested in this study ? Many thanks, David.

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  57. Kathrine Pattrick Saturday, 1 July 2023 at 09:50 AM

    Despite taking six medications for hypertension I still regularly have bp readings of over 200. Ironically, on waking the readings can start at 187 which, within 1 1/2 hours will drop to around 96. I would very much welcome further tests to ascertain the cause of this problem. I live within Greater London.

  58. Timothy Cox Friday, 11 August 2023 at 03:45 PM

    I would like to take part in this trial as I am on perindopril and am experiencing side effects please help me

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